2009-05-01

Background: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical 

Green color indicating a high dGEMRIC index. (good cartilage status and good predictive value for reorientating surgery). Conclusion: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early   volunteers there was a decrease in the dGEMRIC index (T1(Gd)) between 30 and 100 min. In patients the wash-in of Gd-DTPA2– was faster, with a low T1(Gd)   The three established dGEMRIC indices did not accurately predict the intraoperative acetabular localized chondral damage in non-arthritic hips.

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Among those treated nonoperatively, no cor-relation between baseline dGEMRIC indices and change in PROMs was found. In the posterosuperior quadrant, the dGEMRIC index was higher for patients with intact carti-lage compared with hips with chondral lesions A low dGEMRIC index has been associated with failure of the Bernese periacetabular osteot-omy in adult patients with DDH12, presumably because it can differentiate the cases where the OA disease process has advanced too far from those where the cartilage composition is relatively normal. Furthermore, dGEMRIC is sensitive enough to show dif- dGEMRIC indices similar to those from their matched controls and in the normal range for hip cartilage. In all but one of the eight subjects the anterior dGEMRIC index was lower than that in the posterior region. Average T1 for Four Slices Patient T1 (ms) Control T1 (ms) No. Sex/Age Anterior Posterior Sex/Age Anterior Posterior 1 F-19 630 569 F In a previous dGEMRIC study using bulk (full-thickness) index values, we found higher dGEMRIC index interpreted as better cartilage quality in exercising compared to sedentary healthy volunteers .

Quantitative MRI (qMRI) assessment of cartilage morphology has been validated in joints with thin cartilage plates (6) but has not been used to describe local acetabular and femoral cartilage morphology. 10 List of Papers I Tiderius C J, Tjörnstrand J, Akeson P, Sodersten K, Dahlberg L, Leander P. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): intra- and interobserver va Current students New students International Desk Academic matters & support IT services & support Careers Service The dGEMRIC index and indentation stiffness were highly correlated within regions, within cartilage from the same joint, and across cartilage from all the joints, so long as the dGEMRIC index from The patients were divided into two groups on the basis of their dGEMRIC index.

DGEMRIC-indexet korrelerar med proteoglykaninnehåll i brosk och minskas i OA, i överensstämmelse med vävnadsglykosaminoglykanförlust [ 35, 36]. I tidig OA 

Methods One hundred and forty-eight women (one knee for each subject) aged ≥40 years were included To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA 2−) as alternatives at dGEMRIC. average dGEMRIC index as well as slice 2, as an early measure of OA, appears to help identify patients who will not benefit from a joint reconstruction procedure.

Usando esta evaluación indirecta del cartílago articular, se compararon los índices dGEMRIC en un grupo de pacientes de seis levas y siete de pinza a un 

A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error. Thus, a higher dGEMRIC index indicates healthier cartilage (Fig. 1) [ 59 ]. Similar to the knee [ 4, 34 ], dGEMRIC is a promising tool to quantify cartilage healing or degeneration before and after joint-preserving hip surgery and to monitor the natural course of hip diseases. The dGEMRIC index was calculated as the average of the T1 values for the acetabular and femoral head cartilages.

Key words magnetic resonance imaging, dGEMRIC, early rheumatoid arthritis, methotrexate therapy 2018-05-09 2009-05-01 2018-05-16 dGEMRIC index with quantitative measures of proteoglycan content and with semi-quantitative histologic scores3. A lower dGEMRIC index has been associated with regions of hyaline * Address correspondence and reprint requests to: T.E. McAlindon, Division of Rheumatology, Center for Epidemiologic Based Research, Tufts Medical Center, Box We performed a prospective cohort study to evaluate the dGEMRIC index of articular hip cartilage and the morphologic changes in the labrum, cartilage, and bone preoperatively and at twelve and twenty-four months following periacetabular osteotomy for correction of developmental dysplasia of the hip. lesion on the femoral head or neck exists. The dGEMRIC is evaluated for labral tears, chondral flaps, bony edema, and the dGEMRIC index. Patients with joint space narrowing or significant chondral injury are not considered for PAO. Patients with mild dysplasia, a lateral center-edge angle of 20 to 25 , may be considered for arthroscopy alone.
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The dGEMRIC index was 20–30 % lower in the patients with early OA compared to healthy volunteers (P < 0.003) at all time points, with largest difference at the earlier time points due to faster wash-in of the contrast in the OA cartilage. 2014-11-01 Those who decreased their physical activity showed a significant decrease in dGEMRIC index in the medial weight-bearing cartilage. Conclusions: The higher pre-contrast T1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The dGEMRIC index has been shown to be affected by factors, such as exercise , body mass index , and early-stage OA . This imaging method has been validated in clinical studies comparing histological and biochemical measurements of GAG content ( Figure 9 ) [ 104 ].

Agreement between the techniques was assessed using intraclass correlation coefficients (ICC). The dGEMRIC index was lower in SCFE hips than unaffected hips 456 ms (CI 419–493) vs 521 ms (CI 476–567) (P = 0.03).
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dGEMRIC index with quantitative measures of proteoglycan content and with semi-quantitative histologic scores3. A lower dGEMRIC index has been associated with regions of hyaline * Address correspondence and reprint requests to: T.E. McAlindon, Division of Rheumatology, Center for Epidemiologic Based Research, Tufts Medical Center, Box

The dGEMRIC index was assessed on MRI according to established protocol. Regression analysis adjusted for age, sex, body mass index (BMI), and presence of clinical knee OA. Mean age and BMI were dGEMRIC index in the medial weight-bearing cartilage. Conclusions: The higher pre-contrast T 1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The uptake of contrast was found to be from the superficial region of In the posterosuperior quadrant, the dGEMRIC index was higher for patients with intact cartilage compared with hips with chondral lesions (592 ± 203 ms versus 444 ± 205 ms, p < 0.001). CONCLUSIONS We found a decline in acetabular, femoral, and regional dGEMRIC indices for the surgically treated group at 1-year followup despite an improvement in all PROMs. The dGEMRIC index was calculated as the average of the T1 values for the acetabular and femoral head cartilages.

2018-04-01 · The dGEMRIC index was calculated as the mean T 1Gd of all voxels in each of the nine ROIs. An intraobserver analysis for T1 analysis was made in 10 randomly selected SCFE hips. The alpha angle was measured in T1 parasagittal images as defined by Nötzli 24 .

The technique assumes that the plasma levels of the contrast agent Gd-DTPA2− are the same across individuals after intravenous (IV) injection, when dosing by weight. However, adipose tissue has lower extracellular water (ECW) than lean tissue. The aims of this study were to measure In Study III, those who increased their physical activity showed a significant increase in dGEMRIC index in both superficial and deep layers in lateral weight-bearing cartilage. Those who decreased their physical activity showed a significant decrease in dGEMRIC index in the medial weight-bearing cartilage.

(good cartilage status and good predictive value for reorientating surgery). Conclusion: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early   volunteers there was a decrease in the dGEMRIC index (T1(Gd)) between 30 and 100 min. In patients the wash-in of Gd-DTPA2– was faster, with a low T1(Gd)   The three established dGEMRIC indices did not accurately predict the intraoperative acetabular localized chondral damage in non-arthritic hips. The CAL index  19 Aug 2015 Our study aimed to determine whether dGEMRIC indices are predictive of Twelve of the sixty-four hips had a dGEMRIC index of <323 msec  Preoperative delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) for patients undergoing hip arthroscopy: indices are predictive  10 Nov 2016 (3) Is there a correlation between the baseline dGEMRIC index and the change of dGEMRIC indices of femoral and acetabular cartilage were  dGEMRIC (delayed Gadolinium Enhanced MRI of Cartilage) is a technique for T1(Gd), has been used as the dGEMRIC Index in a number of studies to  Background: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical  dGEMRIC. At 33–44 test locations for each tibial plateau, the load response to focal indentation was measured as an index of cartilage stiffness. Overall, a high   dGEMRIC indices in obese subjects with and without clinical knee negative correlation between serum leptin and lateral dGEMRIC index in women (r = – 0.39,  (dGEMRIC) index, subchondral bone marrow abnormality scores, and clinical in the dGEMRIC index in the lateral tibial plateau were greater in the JOINS  3 Mar 2017 (MR) imaging of cartilage (dGEMRIC) indexes ac- quired with different gadolinium-based contrast agents (GB-. CAs), with emphasis on the  29 Jun 2011 Thereby, subsequent T1 measurement in cartilage described as dGEMRIC index or T1Gd reflects the GAG content within a certain cartilage  6 Nov 2013 Study protocol.